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Neurodegenerative diseases and oxidative stress

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Haikal C, Chen QQ, Li JY

V., Vries, M

Upon entering the mouth, approximately 20% of dietary nitrate is immediately converted to nitrite by commensal facultative anaerobic bacteria found under the tongue ( Stimulation of NO production via the NOS-independent pathway Although several investigations have provided insight into the impact of the NOS-independent pathway, research has yet to reveal the specific stimuli required to initiate this pathway ( Exercise as a stimulant for NO production via the NOS-independent pathway The two conditions mentioned above (hypoxia and/or acidosis) commonly occur with high-intensity and intermittent exercise ( Functions of NO in the vasculature Once synthesized, NO is involved in several physiological functions