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In murine models, it was observed to possibly enhance bradykinin-mediated relaxation in certain arteries, likely through mechanisms involving endothelium-derived hyperpolarization

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These grading scales include the Ajani Sensory, Eastern Cooperative Oncology Group (ECOG), National Cancer InstituteCommon Terminology Criteria for Adverse Events (NCICTCAE), and World Health Organization (WHO) systems, which grade CIPN severity on a scale of 0 (normal) to 5 (death)

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