In vivo , FTO knockdown significantly elevates YTHDF2 expression in the striatum of PD mice, inhibits m 6 A demethylation of BAP1 and reduces BAP1 expression, upregulates SLC7A11 expression, decreases -Syn, MDA, Fe 2+ , and 4-HNE levels, suppresses neuronal ferroptosis and disruptions in the amino acid antioxidant system, and promotes dopaminergic neuronal survival in PD mice (Li et al., 2025c)
Several factors can cause glutathione deficiency, such as poor nutrition, exposure to environmental toxins, chronic stress, and the natural aging process
Pediatrics 128, 11811185
Banati et al., 2000)
In this study, we correlated the angiogenic effect of BPC 157 with VEGF expression using in vitro and in vivo models