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If neurological symptoms worsen or fail to improve after four to six weeks of appropriate treatment , further investigation is necessary to exclude alternative diagnoses or complications

Its anabolic and growth-promoting effects are largely indirect, primarily via stimulation of hepatic IGF-1 production, whilst its direct metabolic effects, particularly those related to lipid metabolism and adipose tissue regulation, are believed to be mediated by specific domains within the GH molecule itself

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[DOI] [PubMed] [Google Scholar] 12.Borglum JD, Vassaux G, Richelsen B, Gaillard D, Darimont C, et al