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In the H 2 O 2 -induced melanocyte model, Hyp protected melanocytes from oxidative damage by regulating the PI3K/Akt pathway, inhibiting p38 phosphorylation and suppressing mitochondrial apoptotic signaling, which included upregulation of the Bcl-2/Bax ratio and expression of Akt, and downregulation of caspase 3, p38 (Yang et al., 2016)

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It could be that FOXO4-DRI merely lowers the threshold for cells to enter apoptosis after DNA damage

HRP-conjugated goat anti-mouse IgG or anti-rabbit IgG (Boster, Wuhan, China) was used as the secondary antibody