A substantial body of research has confirmed the positive effect of polyamines on human health, including potential benefits in cancer [256], age-related diseases [70], and neurodegenerative diseases [188]
131,132 TCR deficiency leads to an increase in hepatocyte apoptosis and significant inhibition of hepatocyte replication, and T cell deficiency induces a compromised mechanism to increase the number of T cells involved in the liver regeneration process
Few receptors for DHA and EPA derivatives are known and most of them are highly expressed in microglial cells such as PPARs (75, 76)
In chronic inflammatory states (e.g., rheumatoid arthritis, atherosclerosis), EPA plus DHA supplements have been shown to reduce symptoms of rheumatoid arthritis and the risk of cardiac events
10.1113/jphysiol.2004.063388 416 SunJ.LiH.JinY.YuJ.MaoS.SuK.-P.et al