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Exposing cerebral mitochondria to THC was reported to induce a ten-fold increase in free radical leak and increased H 2 O 2 production [40], while in epithelial cells, THC upregulated inflammation-related genes and downregulated antioxidant-related genes [34]

All vaccinations in this study were administered by hand to a depth of 1.5 inches (3.81 cm, needle hub) into the lower gluteal or proximal biceps femoris using a 22 G needle and 2-ml luer lock syringe under trained behavioural restraint

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Diet descriptions, compositions and item numbers are provided in Supplementary Data 1

The Source Data and Supplementary Information are provided with this paper