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Indeed translocation of mTORC1 from the cytoplasm to the lysosome, a rich compartment in amino acids, is critical for mTORC1 activation ( per se is also able to regulate mTORC1 activity ( In brief, activation of the GCN2-ATF4 amino acid stress pathway and inhibition of protein synthesis through inhibition of mTORC1 demonstrates the strong proteogenic role played by cysteine in tumor cells

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Toutefois, le glutathion utilis nest pas perdu : une enzyme spcifique contenant du slnium, la glutathion rductase, reconvertit le GSSG en deux molcules de glutathion actives, prtes repartir la chasse aux radicaux libres