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The charge inversion in K105E further enhanced the effects

Notably, some studies have shown that vitamin K1 (chlorophylquinone) can compensate for the damage to the anti-ferroptosis defense mechanism when GPX4 was inhibited or when used with the DHODH inhibitor BQR, and its anti-ferroptosis efficacy was found to be equivalent to that of ferrostatin-1 (Fer-1) [61]

71 Van MeerG.SimonsK

Conversely, elevated pyroglutamic acid, a byproduct of glutathione metabolism, was observed in the MMA group, reflecting increased glutathione turnover and impaired recycling under oxidative stress conditions [48], further supporting the profound redox imbalance in MMA

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