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Researchers became interested when early studies revealed that these peptides dont just work in parallelthey actually enhance each others mechanisms

They appear after each dose increase, peak during the first week at the new dose, and gradually subside over 2 to 4 weeks

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Physiological Actions The physiologic effects of neurosteroids are mediated through direct interactions with neurotransmitter receptors and transporters, and indirectly via promotion of second-messenger signaling cascades (99103)