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Eukaryotic COG0523 Proteins Landmark studies published in 2022 establish that a eukaryotic COG0523 protein, named ZNG1 for Zn-regulated GTPase metalloprotein activator 1, fulfills all the criteria that one would anticipate of a metallochaperone for methionine aminopeptidase-1 (METAP1) in vertebrates and the yeast Saccharomyces cerevisiae , a finding recapitulated recently in plants

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Poor absorption of vitamin B 12 may be due to: alcoholism bowel disease, such as Crohn disease, celiac disease or a parasitic infection prior surgery that removed portions of the stomach or small intestine chronic use of medications for ulcers or heartburn such as antacids lack of a protein called "intrinsic factor" This protein is needed to absorb vitamin B 12 from the diet

References: Heiman, M