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doi: 10.1038/s41598-024-74791-2 11

The F1 generation demonstrates 45% sperm count reduction and 38% testosterone decrease, while the F2 generation exhibits persistent sperm motility and morphological abnormalities attributable to heritable DNA methylation changes

L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH) [2]

In addition, tar builds up in the lungs from cigarette smoke particles and processes, producing an aqueous solution that goes through redox cycling to produce different reactive species, causing damage subsequently (61)

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