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In rats given BPC-157, serotonin levels in the brain increase in specific regions while simultaneously decreasing in other regions, such as the hippocampus.[ref] A 2020 study found that BPC-157 reduced leaky gut syndrome by stabilizing gut permeability after NSAID use.[ref] Reducing leaky gut theoretically can affect the gut-brain axis and reduce inflammation

Cho HJ, Lavretsky H, Olmstead R, Levin MJ, Oxman MN, Irwin MR

It could be the fact that the hand or finger is not exposed to things out in the world