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At present, the literature on the inhibitory effect of metformin on glioma stem cells mainly focuses on the studies on the AMPK-mTOR/STAT3, AMPK-FOXO3 and AMPK-P13K/AKT pathways of MET ( Figure 3 )

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The strategy for pathogen recognition is based on host germline-encoded pattern recognition receptors (PRRs) identifying unique pathogen-associated molecular patterns (PAMPs)