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For the extrinsic pathway, extracellular ligands bind to the death receptors, leading to formation of death-inducing signaling complex that then cleaves procaspase-8 to caspase-8 (Franklin, 2011)

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Hydrogen peroxide inhibits hepatitis C virus replication by downregulating hepatitis C virus core levels through E6-associated protein-mediated proteasomal degradation

[PubMed: 29931273] 25

Clinical translation and therapy Although preclinical evidence strongly supports targeting multiple RCD pathways in AML, clinical translation faces challenges due to variable patient responses (18)