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At physiological pH, H 2 S (pKa ~7) exists predominantly (~70%) as the hydrosulfide anion (HS ) while the conjugate acid freely diffuses through biological membranes to access the catabolic machinery within mitochondria 4

Once p53 is freed, it moves out of the nucleus toward the mitochondria and sets off the intrinsic apoptosis pathway (a caspase-driven self-destruct program)

Histopathological Evaluation Incisional punch biopsies (diameter: 3 mm) of the hair skin were obtained at baseline and after 2 months from the last PRP treatment, and fixed in buffered formalin