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Plasma samples were thawed in batches of approximately 20 to minimize thaw time

AM404 acts on the transient receptor potential vanilloid 1 (TRPV1) and cannabinoid 1 (CB1) receptors in the midbrain and medulla (Roberts et al., 2002

For these six subjects, baseline GSH levels were all assigned the same value (the lowest measured GSH/Cr ratio value across all subjects and scans, divided by 2), in order to calculate the absolute change in GSH/Cr ratio relative to baseline

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Caetano-Silva ME, Rund LA, Vailati-Riboni M et al (2021) Copper-binding peptides attenuate microglia inflammation through suppression of NF-kB pathway