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Most clinical studies have examined these substances independently rather than in combination, so the safety profile and potential synergistic or additive effects remain inadequately characterised
AJC 12 , 66616665 (2013) Dolui, B.K., Bhattacharya, S.K., Kundu, K.K.: Solvent effect on deprotonation equilibria of acids of various charge types in non-aqueous isodielectric mixtures of protic ethylene glycol and dipolar aprotic N , N -dimthylformamide at 298.15 K
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This approach is more invasive and may result in scarring, so it is usually reserved for cases where other treatments have failed
