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Reading the mechanism this way copper first, everything else downstream is also what keeps the safety discussion honest, because the very property that makes the biology interesting is the property that creates the systemic risk

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Initially synthesized as a single-chain monomeric proenzyme (3234), DPP1 spontaneously folds into the proDPP1 homodimer containing an exclusion domain, a propeptide, and both heavy and light chains that form a papain-like catalytic domain ( Figure 3 ) (32, 33)

These compounds work through entirely different mechanisms, making direct comparison difficult