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Description

Didymin suppresses microglia pyroptosis and neuroinflammation through the Asc/Caspase-1/GSDMD pathway following experimental intracerebral hemorrhage

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Free Radic Biol Med 63:5164 Schrammel A, Gorren AC, Schmidt K, Pfeiffer S, Mayer B (2003) S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-)

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doi: 10.1016/j.freeradbiomed.2006.02.013

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10 Factors such as ethanol catabolism, lactic acid inhibition of renal urate excretion, acute liver damage, and fructose consumption affect the production of UA metabolic enzymes and UA transporters, 59 or intensify adenosine triphosphate degradation, 60 contributing to elevated serum UA levels following alcohol or fructose intake

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In addition, AOX reduces the overall level of 02, the substrate for ROS production, in the organelle

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