Didymin suppresses microglia pyroptosis and neuroinflammation through the Asc/Caspase-1/GSDMD pathway following experimental intracerebral hemorrhage
Free Radic Biol Med 63:5164 Schrammel A, Gorren AC, Schmidt K, Pfeiffer S, Mayer B (2003) S-nitrosation of glutathione by nitric oxide, peroxynitrite, and (*)NO/O(2)(*-)
doi: 10.1016/j.freeradbiomed.2006.02.013
10 Factors such as ethanol catabolism, lactic acid inhibition of renal urate excretion, acute liver damage, and fructose consumption affect the production of UA metabolic enzymes and UA transporters, 59 or intensify adenosine triphosphate degradation, 60 contributing to elevated serum UA levels following alcohol or fructose intake
In addition, AOX reduces the overall level of 02, the substrate for ROS production, in the organelle