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GPER is highly expressed in brown adipocytes, and its levels are closely correlated with the functional state of adipose tissue [211, 212]

PMCID: PMC10708302

This property allows them to: Cross cellular membranes Interact with fatty tissues Influence nervous system structures Persist beyond the initial exposure period Because fat-soluble compounds are not cleared as rapidly as water-soluble substances, symptoms may continue even after a person leaves the water-damaged environment

Iitaka M, Miura S, Yamanaka K, Kawasaki S, Kitahama S, Kawakami Y, Kakinuma S, Oosuga I, Wada S, Katayama S

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