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These findings suggest oral administration can be effective, at least in rodent models

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Blastocysts grown from oocytes fertilized with sperm that had been exposed to XXO displayed decreased blastocyst developmental competence by increasing blastomere DNA fragmentation (86)

In its copper-bound form, the peptide exhibits biological activity that the free apopeptide (GHK without copper) largely cannot replicate, noting that the copper ion is critical for the compounds regenerative and redox-active properties