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In economically developed countries, smoking prevalence has decreased among all age groups (in the USA, most steeply amongst those 10,000 patients from three independent cancer centres revealed that the proportion of LCINS relative to total NSCLC diagnoses increased from 8.0% in 19901995 to 14.9% in 20112013 ( P 85%), without a preponderance of one alteration relative to the other 7 , although the L858R mutation and exon 19 deletions seem to occur more frequently in older and younger patients, respectively 18,81