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GSH concentration is instead measured by either of two methods: by analysis of GS-NEM conjugates by HPLC in the same sample that is used to measure GSSG or, alternatively, by analysis of GSH by spectrophotometry (GSH recycling method) on one additional sample aliquot that has not been derivatized with NEM

Common adverse effects include bradycardia, gastrointestinal hyperactivity, and fasciculations

In the treatment of RA, natural products can be used to treat RA through multiple pathways by regulating the activation of Nrf2 through their advantages of targeting multiple proteins and pathways

PMID: 41057744

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