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By blocking NNMT, 5-Amino-1MQ modulates intracellular NAD+ pools and related metabolic pathways

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The predicted P eff value for D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 (1.53) is intermediate between the predicted P eff values for enalapril (1.25) and piroxicam (2.14), two orally bioavailable drugs

This dual mechanism explains why the compound produces such pronounced effects on adipose tissue lipid content without affecting lean tissue or overall energy intake in research models

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