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However, in a depleted state, these defenses fail

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Arch Physiol Biochem 128(4):938944 Murakami A, Kitazono Y, Jiwajinda S, Koshimizu K, Ohigashi H (1998) Niaziminin, a thiocarbamate from the leaves of Moringa oleifera , holds a strict structural requirement for inhibition of tumor-promoter-induced Epstein-Barr virus activation

This reduction in GPX3 expression leads to an imbalance in extracellular redox homeostasis, ultimately promoting cancer development (46)