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LC conditions: Separation of ceramide species was performed on an Agilent 1200 series HPLC system (Agilent Technologies, Palo Alto, CA) using an Ascentis C18 column (5 cm 2.1 mm I.D., 3 m particle size, Supelco, Bellefonte, PA)

Symptoms include pain in the fingers and toes, loss of sensation, cold or mechanical allodynia and mechanical weakness

When a manufacturer understands these requirements and can provide the necessary documentation in advance, it helps brands avoid delays or compliance challenges during the product launch process

However, the effect varies, is not guaranteed, and the evidence is still limited

Avoid contact with eyes and discontinue if irritation persists