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A third thread is angiogenesis and cell recruitment

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As a tripeptide, GHK-Cu is particularly small and susceptible to rapid enzymatic cleavage in the stomach and small intestine

GHK-Cu modulates gene expression across tissue remodeling pathways, including upregulation of collagen types I and III, decorin, and tissue inhibitors of metalloproteinases, while delivering copper to copper-dependent enzymes like lysyl oxidase and superoxide dismutase