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TrkA activation similar to TrkB, triggering PI3K/Akt and MAPK pathways

& Harper, M

Collectively, these factors establish a transcriptional framework that governs the core machinery of autophagy initiation, progression, and organelle turnover, integrating stress signals and nutrient availability into precise gene expression responses essential for cellular homeostasis and adaptation

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Research in APP/PS1 Alzheimer's mice demonstrates that Dihexa treatment markedly reduces activation of astrocytes and microglia, the brain's primary inflammatory cells