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Ferritin, another target of IRP1 and IRP2, binds free cellular iron and prevents ferroptosis (LaVaute et al., 2001)

So when the barrier becomes more permeable, the proposed mechanism is straightforward: substances that should stay in the gut lumen bacterial fragments, undigested food particles, pathogens cross into deeper tissue and the bloodstream, where they can drive immune activation and an increased antigenic and toxic load

Olszewski AJ and McCully KS (1993)

[14] [15] In those studies, the lowest dose (600 mg) tended to be as well-tolerated as placebo, with no significant difference in adverse events compared to placebo