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In addition, none of these measurements distinguishes changes in pre- vs

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GS hematin stability in the presence of hydrogen peroxide The degradation of hematin in the presence and absence of GSH (2 mM) induced by H 2 O 2 was monitored by the change of absorption at 618 nm

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Interestingly, a specific GPX1 polymorphism resulting in a proline-to-leucine transition at position 198 (Pro198Leu) is associated with a reduction in GPx1 activity and found to be more prevalent in Keshan patients

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