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It is recruited to shelterin through a domain:peptide interaction between its TRF homology (TRFH) domain, also responsible for dimerisation of TRF1 (TRF1 TRFH ), and a short linear motif of TIN2, known as its TRFH-binding motif or TBM (TIN2 TBM

"Scarring: current concepts and practical approaches." Journal of Wound Care , 8(5), 207-214

It also stimulates collagen production for stronger, more elastic skin

Engaging both receptors effectively manages blood sugar levels, boosts insulin release, decreases glucagon production, and slows down gastric emptying

The absence of a significant effect with CBBBP alone suggests that the CBBBP construct may require the DSIP component to engage with the relevant neural pathways effectively