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Evidence from type 1 diabetes also points to an increase in GSH utilization, which in itself was associated with poorer glucose control.The perfect storm of obesity, oxidative stress, inflammation, adipocyte dysfunction, and the related metabolic abnormalities may also be linked by glutathione depletion

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Halpin LE, Yamamoto BK (2012)

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Additionally, clearance of these particles from the bloodstream (via the liver and spleen) is inversely related to size: the smallest particles circulate the longest, increasing the likelihood of absorption at their target tissues