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Adsorptive-mediated transport at the BBB has also been exploited to target nanocarrier systems by using cationic lipids and cell penetrating peptides to increase binding and internalization at the brain capillary endothelium [29, 30], which has a highly negative surface charge [31]

The timing of dox or cisplatin treatment is indicated as Day 0 by a dark blue line, with lighter dashed lines for subsequent 50-day increments

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