doi: 10.1105/tpc.010256 219 TangJ.ZhangJ.RenL.ZhouY.GaoJ.LuoL.et al
The mechanisms are still being studied, and causality remains to be established in randomized trials, but the association is notable for how cancer survival is modeled across populations
In children, it is most commonly associated with sulfa drugs and anticonvulsants.1 Typically, the clinical picture develops between 4 and 28 days (most frequently 1015 days) after starting treatment.2 Involvement of the oral, ocular, gastrointestinal, and genital mucosa is very common.1 The incidence of EN and the associated mortality appear to be lower in children than adults
It's not part of the guidelines
Differences in diagnosis accuracy, inflammatory load, sleep, metabolic health, and biomechanics can make the same therapy look powerful in one person and ineffective in another