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Second, informative injury models need to mimic the injuries seen in sporting environments (Wall and Shani, 2008), yet most brain injury models create focal hemorrhagic cortical lesions caused by direct impact to the skull or exposed brain (Xiong et al., 2013), while the human concussed brain is more commonly associated with distributed white matter alterations (Benson et al., 2007

Once hydroxocobalaminthe form most commonly used in the UKis injected intramuscularly, it rapidly enters the bloodstream, bypassing the gastrointestinal tract entirely

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