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Mitochondrial damage in synovial tissue and oxidative stress environment are key factors in the induction of angiogenesis (183)

McKay DM, Mancini NL, Shearer J, Shutt T (2020) Perturbed mitochondrial dynamics, an emerging aspect of epithelial-microbe interactions

Epithalon, a synthetic tetrapeptide based on pineal gland epithalamin, activates telomerase to maintain or extend telomeresthe protective caps on chromosomes that shorten with age

It is structurally related to tuftsin, an immunomodulatory peptide that plays a role in improving the activity of immune cells such as macrophages and natural killer cells

Additionally, BPC-157 modulates the nitric oxide (NO) system, interacting with both eNOS and iNOS pathways to optimize vascular function