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Restoration of DJ-1 expression ameliorates these defects by enhancing mitochondrial electron transport chain activity and reducing ROS overproduction, thereby attenuating oxidative stress-mediated neuronal damage (McCoy and Cookson, 2011)

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For example, a study in 27 obese women receiving PT-141 showed a decrease in daily calorie intake by 400kcals and an average weight loss of 3.7lb over 16 days, surpassing the 2lb loss observed in the placebo group [9]

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Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability