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Subsequently, the rats were placed with a 50 g sawdust and 0.682 g of cigarettes (tar 13.5 mg/G, nicotine 0.48 mg/g) mixed combustion smoke chamber

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Additionally, TB-500 has been found to exhibit immunomodulatory effects by preventing apoptosis through cytochrome c release inhibition and modulation of BCL-2 expression and caspase activation [10]

On this basis, we posit that the therapeutic action of Erastin in EMS is critically mediated by these ROS-driven programs, and that pharmacologic suppression of mitophagy may further sensitize lesions to Erastin

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