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The mitochondrial TCA cycle plays an important role in the occurrence of cuproptosis, in which protein lipoylation is specific to the four proteins: dihydrolipoamide branched-chain transacylase E2 (DBT), glycine cleavage system protein H (GCSH), dihydrolipoamide S-succinyltransferase (DLST), and DLAT, involved in this cycle [60]

Nrf2 mediates the DNA methylation level of RANKL promoter by regulating the activity of DNA methyltransferase 3a, participating in the regulation of ferroptosis in osteoclasts and bone homeostasis

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The CagriSema combination represents the most likely initial approval pathway, with regulatory submissions expected