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The reaction between RT and GSH is based on a Michael addition reaction that is inherently reversible, has an appropriate dissociation equilibrium constant K d in the mM range and rapid reaction kinetics, and provides ratiometric readouts, thus allowing GSH quantification independent of the probe concentration

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[DOI] [PubMed] [Google Scholar] 85.McCord JM

( 18)F-FDG-PET detects drastic changes in brain metabolism in the Tg4-42 model of Alzheimers disease

33,34,35,36,37 One study suggests that length of time from diagnosis of cognitive impairment is important for response rate, in that patients who had experienced symptoms for less than 12 months improved on B12, whilst those with symptoms for more than 12 months continued to decline