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Compared to placebo, it has been shown to significantly lower HbA1c by up to 2.07% when administered as a once-weekly subcutaneous injection at a maximum dose of 15 mg

MOTS-c has a short half-life (46 hours), so missing a single dose doesn't create long-term metabolic disruption, but it does interrupt the AMPK activation pattern for that 48-hour window

Individuals considering extended protocols should discuss this temporal limitation with healthcare providers and maintain appropriate monitoring throughout treatment

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Methotrexate and trimethoprim-sulphamethoxazole: extremely serious and life-threatening combination