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They are part of a rapidly expanding class of incretin-based medications that includes several other notable compounds

Diamond T.H., et al

FIGURE 5 Next, we focused on antioxidant enzymes because they primarily regulate the level of ROS, a major cause of oxidative stress

doi: 10.1166/jbn.2023.3720 183 FangWXieSDengW

In a placebo-controlled study of 70 -amyloid positive patients with either amnestic mild cognitive impairment (a precursor to AD) or mild AD, those receiving 600 mg/day of benfotiamine for 12 months experienced less cognitive decline compared to placebo, but the differences did not reach statistical significance (p=0.125