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Rose et al 2023 demonstrated that certain chemotherapeutic drugs such as talazoparib, camptothecin and etoposide binds and traps proteins (PARP and topoisomerases I and II, respectively) on DNA strands, resulting in DNA damage and double-strand breaks

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Immunoprecipitation is one of the most broadly used methods for separating proteins and other biomolecules from tissue or cell lysates for subsequent detection via western blotting & other assay methods

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