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In normoxic conditions, pyruvate enters the mitochondria and is completely oxidized to CO 2 and H 2 O via the TCA cycle

PINK1 and Parkin, best known for their role in mitophagy, are also central to maintaining neuronal quality control (Fig

Amino acid metabolism Myeloid-derived suppressor cells (MDSCs) exploit multiple amino acid metabolic pathways to establish and sustain immunosuppression in the tumor microenvironment (7)

Glutathione directly and indirectly (through boosting immunity) affects inflammation processes and thereby relieves associated pain