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Furthermore, the threshold effect is consistent with the concept that methionine synthase activity may become saturated beyond a certain B12 concentration [17], explaining the diminishing returns observed at higher levels

It is a well-characterized, mechanistically specific peptide with a 30-year research history, a strong clinical safety record from formal trials, and modest but real efficacy data from 12-week studies

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You can find B12 naturally in foods like meat, fish or dairy products

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Wang Y, Kory N, BasuRay S, Cohen JC, Hobbs HH