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For the majority of people, I recommend once weekly for 4 weeks

B12 is an essential nutrient, and its deficiency is common, especially among individuals following restricted diets like vegetarianism or veganism, pregnant or breastfeeding women, older adults, those who have undergone gastrointestinal surgery or have gastrointestinal disorders, and people with an autoimmune condition known as pernicious anaemia

Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue

Physicians Committee for Responsible Medicine