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Moreover, OW semaglutide 2.4 mg was associated with a consistent benefit in HF composite endpoint, comprising death from CV causes or hospitalization or an urgent medical visit for HF (HR 0.82, 95% CI, 0.710.96), and death from any cause (HR 0.81, 95% CI, 0.710.93) 84

First, the vast majority of available data derives from animal studies, and extrapolation to human applications may not be straightforward due to species differences in physiology and drug metabolism

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