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What they found: No serious adverse events triggered by AOD-9604 The most frequent side effects: headache (~5 %), occasional fatigue, at the same frequency as placebo No changes in IGF-1 levels, glycemia, blood pressure, heart rate No signals of cardiovascular, hepatic or renal toxicity Safety profile comparable to placebo Why it matters: From a safety perspective, AOD-9604 is one of the safest peptides in the clinical registry

Mice fed with corn peptides alongside an HFD mitigated weight gain and adverse effects on the liver

Proper dosing is needed to achieve optimal blood sugar control and minimize the risk of side effects

doi: 10.1097/MOH.0b013e328345a3d1 11 WoodfinAVoisinMBBeyrauMColomBCailleDDiapouliFMet al

Feldman, S