Functional complementation of the H 2 O 2 -sensitive yeast growth by transforming GhGPXs in gpx3 mutant yeasts The GPX homolog YIR037W / HYR1 / GPX3 was found in the Saccharomyces Genome Database, and a previous study indicated that gpx3 mutant was hypersensitive to peroxides, and with decreased ~57% GPX activity in gpx3 mutants with respect to wild type (BY4741) 47
This leads to the dissociation of TIMELESS from the replisome, slowing replication and resulting in replication stress and genome instability 17
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